Asante Kotoko goalkeeper is set for two weeks on the sidelines after sustaining a training ground injury.
The shot-stopper rejoined the Porcupines last week after leaving for national assignment with the Black Stars during the November international break.
Annan was an unused substitute in both games where Ghana beat South Africa 2-0 and Sao Tome 1-0 on the road.
But days after returning to the team, the Kotoko captain has suffered an ankle problem club sources tell starrsportsgh.com could keep him out for at least two weeks.
The timeline gives fans of the club some huge relief as Annan could return to fitness in time for the start of the new Ghana Premier League.
The 2019/20 GPL is set to get underway on the weekend of December 27-29.